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红细胞分布宽度和高血压:从NHANES2021到2023年的研究和MR-PRESSO调整的门德尔随机化分析的关联

Zihao Zhao¹, Yuhong Ma, Weizhong Huangfu

¹Department of General Practice, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, China.

|December 16, 2025

概括

高血压可能导致红细胞分布宽度 (RDW) 的增加,这是心血管事件的标志物. 13.8%的RDW值可能表明在没有先前心血管问题的患者中,高血压风险增加.

科学领域:

心血管疾病流行病学
遗传流行病学遗传流行病学
生物标志物研究生物标志物研究

背景情况:

高血压是一种全球性慢性疾病,与红细胞分布宽度 (RDW) 有着不清楚的关系.
RDW是已知的心血管事件的预后标志物.
传统研究面临诸如混因素和逆因果关系等挑战,以确定RDW与高血压的联系.

研究的目的:

为了研究红细胞分布宽度 (RDW) 和高血压之间的因果关系.
确定与高血压风险相关的潜在RDW值.
使用孟德尔的随机化探索协会的方向性.

主要方法:

一种混合方法方法,将观测数据 (NHANES 2021-2023) 和孟德尔随机化 (MR) 结合起来.
观察分析使用多变量逻辑回归和受限立方线.
在MR分析中,采用了MR-PRESSO调整的56个仪器变量,并补充了IVW和MR-Egger灵敏度分析.

主要成果:

每增加1个单位的RDW与13%更高的高血压风险有关 (OR=1.13).
观察到非线性值效应,当 RDW < 13.8% (OR = 1.29) 时,相关性更强.
核磁共振分析表明高血压因果上升RDW (OR=1.36),没有显著的水平性.

结论:

高血压可能导致增加RDW.
13.8%的RDW值被确定为可能对高血压风险显著.
RDW可以作为监测特定人群高血压风险的参考指标.

关键词:

门德尔的随机化尼汉斯 (NHANES) 是一个名人.这种高血压,高血压.非线性关联是一种非线性关联.红细胞分布宽度红细胞分布宽度

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