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饮食和血栓塞栓症之间的因果关系:一个双样本的门德尔随机化研究

Shuanghui Hu¹, Hanlin Li¹, Lujie Wu¹

¹Emergency Center, Anxi County Hospital, Quanzhou, Fujian, China.

|December 16, 2025

概括

某些饮食可能会影响静脉血栓栓塞 (VTE) 的风险. 这项研究使用了门德尔的随机化来探索饮食和VTE之间的遗传联系,发现某些食物的保护作用和火腿的风险增加. 饮食调整可能有助于预防VTE.

科学领域:

心血管流行病学心血管流行病学
营养科学营养科学
遗传流行病学遗传流行病学

背景情况:

饮食习惯与心血管疾病有关,包括静脉血栓塞栓症 (VTE).
饮食和VTE风险之间的因果关系需要进一步调查.
了解这些联系对于VTE预防策略至关重要.

研究的目的:

调查各种饮食摄入量与静脉血栓塞栓症 (VTE) 风险之间的潜在因果关系.
使用强大的双样本门德尔随机化 (MR) 方法来评估饮食和VTE之间的遗传联系.
为了确定可能增加或减少VTE风险的特定饮食因素.

主要方法:

采用2个样本的门德尔随机化 (MR) 设计,使用来自英国生物银行和FinnGen的全基因组关联研究 (GWAS) 数据.
作为主要的MR分析方法,采用逆变量加权 (IVW).
进行了敏感性分析,包括科克兰Q测试,MR-Egger拦截和留出一个的分析,以评估异质性和性.

主要成果:

鉴定了8种与减少VTE风险相关的饮食因素:黑胡,,咖,桃,,鱼,鱼,沙丁鱼和酒精消费.
发现火腿的摄入量与VTE的风险增加有显著关联.
观察到特定食物偏好 (奶酪蛋糕,加糖咖啡,菜) 与肺栓塞和深静脉血栓形成的风险之间的关联.

结论:

MR 分析支持某些饮食习惯与VTE 发展之间存在遗传因果关系.
饮食修改,包括增加鱼类和植物性食品的消费和减少火腿的摄入量,可能在VTE预防中发挥作用.
需要进一步研究特定的饮食成分及其对VTE病原性的影响.

关键词:

门德尔的随机化分析.饮食饮食饮食饮食食物偏好食物偏好遗传学遗传学遗传学是一个单个核酸的多形态.静脉血栓塞栓症是一种静脉血栓塞栓.

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