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类风湿性关节炎对阿尔茨海默病的影响:一个双样本双向门德尔随机化研究

Songxin Zhong^1,2, Changqiang Feng^1,2, Shizhan Li^1,2

¹Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

|December 16, 2025

概括

类风湿性关节炎 (RA) 因果性地增加了阿尔茨海默病 (AD) 的风险,但AD不会影响RA风险. 在RA患者的早期认知查可能有助于预防AD的进展.

科学领域:

神经科学是一个神经科学.
免疫学免疫学免疫学
遗传学遗传学是一个

背景情况:

类风湿性关节炎 (RA) 和阿尔茨海默病 (AD) 风险之间的关系受到争论,观察性研究仅限于混和反向因果关系.
门德尔随机化 (MR) 提供了一种强大的方法来研究使用遗传变异的因果关系.

研究的目的:

通过双向双样本的门德尔随机化 (MR) 研究,调查类风湿性关节炎 (RA) 和阿尔茨海默病 (AD) 风险之间的潜在因果关系.
为了确定RA是否会增加AD风险,或者AD是否会影响RA发展.

主要方法:

利用来自大型全基因组关联研究数据库和RA和AD的FinnGen项目中的遗传数据.
采用逆方差加权 (IVW) 作为主要的MR方法,并补充了MR-Egger,加权中位数和加权模式分析.
进行了灵敏度分析,包括科克兰Q测试,MR-Egger拦截,MR-PRESSO,留出一项分析和漏斗图表,以评估异质性,性和结果的稳定性.

主要成果:

基因预测的RA对患AD的风险产生了显著的积极因果作用 (IVW OR=1.062,P=0.004).
反向MR分析显示,AD对RA风险没有显著的因果关系 (所有P>0.05).
没有检测到显著的异质性或质性,敏感性分析证实了研究结果的可靠性.

结论:

这项双向MR研究提供了强有力的因果关系证据,表明类风湿性关节炎增加了阿尔茨海默病的风险.
研究结果表明,RA患者的早期认知功能查可能是防止未来AD进展的有价值策略.

关键词:

阿尔茨海默病是阿尔茨海默氏症的疾病.门德尔的随机化这种因果关系是因果关系.类风湿性关节炎类风湿性关节炎

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