身体活动和女性的性类固醇激素:一项前性研究
Kinga Słojewska1,2, Andrzej Galbarczyk1,3, Magdalena Klimek1
1Department of Environmental Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland.
概括
增加女性的体力活动可以降低孕激素水平,减少排卵频率. 这表明定期炼可能有助于调节生殖荷尔蒙,并可能降低与荷尔蒙有关的癌症的风险.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 运动生理学 运动生理学
- 预防癌症 预防癌症
背景情况:
- 女性的生殖功能对能量平衡非常敏感.
- 激素依赖性癌症,如乳腺癌,与高 Estradiol 和孕激素水平有关.
- 定期炼可能会降低这些激素水平和累积的激素暴露.
研究的目的:
- 为了检查增加体力活动对雌激素,孕和健康妇女在连续月经周期中的排卵频率的影响.
- 了解能源消耗与生殖功能之间的联系.
- 探索运动作为调节生殖激素和降低癌症风险的策略.
主要方法:
- 135名健康妇女参加了三个月经周期.
- 循环2和3涉及至少180分钟/周的中度体力活动,通过加速度计测量.
- 从每日的唾液样本中测量了雌激素和孕激素;使用尿路质激素测试监测排卵.
主要成果:
- 循环2的平均每日步数增加了~14%,而在循环3中没有进一步的增加.
- 较大的体力活动增加与周期3中的孕激素水平显著降低有关.
- 排卵发生率从70%下降到39%,但与步数的变化没有直接关系.
结论:
- 仅仅是能量消耗,即使没有负能量平衡,也会改变卵巢功能.
- 适度增加体力活动可以降低孕激素,降低受孕概率和终身荷尔蒙暴露.
- 在绝经前妇女中鼓励定期体育活动对于生殖健康很重要,并可能降低与激素有关的癌症的风险.
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