严重急性COVID-19和多系统炎症综合征 (MIS-C) 在荷兰儿童的肺部后续
Lieke C E Noij1, Caroline L H Brackel2, Mariëlle W Pijnenburg3
1Department of Pediatrics, Division of Pediatric Pulmonology and Allergy, Emma Children's Hospital, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Pediatric pulmonology
|December 16, 2025
概括
住院患有COVID-19或儿童多系统炎症综合征 (MIS-C) 的儿童可能会出现长期呼吸问题. 与MIS-C患者相比,COVID-19幸存者报告了更多的症状和较低的生活质量.
科学领域:
- 儿科重症监护医药 儿科重症监护医药
- 传染病流行病学 传染病流行病学
- 肺部康复治疗 肺部康复治疗
背景情况:
- COVID-19可能会导致严重的呼吸系统疾病或儿童多系统炎症综合征 (MIS-C),需要住院治疗.
- 在重症儿科COVID-19或MIS-C之后,长期健康结果,特别是呼吸道疾病,需要进一步调查.
研究的目的:
- 在MIS-C或COVID-19住院后5-12个月的儿童中评估呼吸道疾病和与健康相关的生活质量 (HRQoL).
- 为了比较患有MIS-C的儿童和患有COVID-19的儿童之间的长期症状的流行率和性质.
主要方法:
- 一个多中心的前性队列研究,涉及儿童 (0-17岁) 住院治疗MIS-C或COVID-19在荷兰医院.
- 后续评估包括临床评估,HRQoL问卷,螺旋测量和心肺运动测试 (CPET).
主要成果:
- 72名儿童中有19%的儿童在住院后8个月的中位数报告了持续的呼吸道症状 (呼吸不全,咳).
- 损伤的HRQoL在COVID-19组 (60%) 比MIS-C组 (14%) 更常见.
- 在两组中都注意到异常的螺旋测量和CPET发现,在COVID-19队列中出现更高的发病率;脱条件是常见的CPET异常.
结论:
- 长期的呼吸系统后果和疲劳是儿童中MIS-C和严重的COVID-19的潜在结果.
- 与MIS-C相比,COVID-19后呼吸系统症状和HRQoL降低的发生率更高.
- 虽然COVID-19相关的异常常常与症状相关,但MIS-C患者有时会表现出CPET变化,而没有同时出现呼吸道投诉或肺功能缺陷.
相关概念视频
01:17Pulmonary Cycle: Exhalation
2.9K
In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
2.9K
01:20COPD: Pathogenesis and Clinical Features
1.7K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.7K
01:29Pneumonia II: Pathophysiology
2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
01:30Pneumonia III: Complications and Assessment
756
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
756
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
3.5K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
3.5K
01:21Acute Respiratory Failure-II
981
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
981