[在乳蛋白过敏性肠炎的婴儿中检测便calprotectin的诊断价值]
Xiaoyi Jia1, Yan Zhang1, Weihong Tang1
1Department of Gastroenterology, Hangzhou Children's Hospital, Hangzhou 310015, China.
概括
便中的calprotectin是诊断婴儿乳蛋白过敏性肠炎的重要指标. 升高的水平与炎症增加相关,并与较高的乙酸性粒细胞 (EOS) 和血小板 (PLT) 计数有关.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 过敏 免疫学 免疫学
- 生物标志物研究 生物标志物研究
背景情况:
- 乳蛋白过敏性肠炎是婴儿常见的疾病.
- 准确和早期诊断对于有效的管理至关重要.
- 便中的calprotectin是已知的肠道炎症标志物.
研究的目的:
- 为了评估便calprotectin的诊断价值在乳蛋白过敏肠炎的婴儿.
- 建立早期诊断和治疗决策的临床基础.
- 为了探索便calprotectin,eosinophilic粒细胞 (EOS) 和血小板 (PLT) 水平之间的相关性.
主要方法:
- 对87名婴儿的临床数据进行了回顾性分析.
- 分类为确定的牛奶蛋白过敏性肠炎 (A组),非过敏性肠炎 (B组) 和健康对照 (C组).
- 测量便calprotectin,EOS和PLT水平;用于诊断价值的ROC曲线分析.
主要成果:
- 与B组和C组相比,A组的便calprotectin,EOS和PLT水平显著更高 (P <0.05).
- 便calprotectin显示出对过敏性肠炎的诊断价值 (AUC=0.758).
- 在便calprotectin和EOS (r=0.325,P <0.05) 和PLT (r=0.280,P <0.05) 之间发现了正相关性.
结论:
- 便中的calprotectin具有重要的临床价值,用于诊断婴儿乳蛋白过敏性肠炎.
- 便中calprotectin水平升高表明更严重的炎症反应.
- EOS和PLT水平可能与便calprotectin正相关,这表明它们作为补充标记物的潜力.
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