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自抗体状态对严重视神经炎患者的视觉结果的影响没有多发性硬化症的患者

Prashant Bhatele¹, Arvind N Prabhu¹, Aparna R Pai¹

¹Department of Neurology, https://ror.org/02xzytt36Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

|December 16, 2025

概括

患有视神经炎的髓类寡干细胞糖蛋白 (MOG) -IgG阳性患者的视力恢复最好,而水-4 (AQP4) -IgG阳性患者的视力恢复最差. 抗体状态是指导视神经炎管理和预测长期视觉结果的关键.

科学领域:

神经科学是一个神经科学.
眼科医生眼科眼科
免疫学免疫学免疫学

背景情况:

视神经炎 (ON) 是年轻成年人视神经病变的主要原因.
有限的纵向数据存在于自身免疫ON亚型的视觉恢复.
这项研究调查了在没有多发性硬化症的严重ON中长期的视觉结果,按自身抗体状态分层.

研究的目的:

评估严重视神经炎患者的长期视觉结果.
根据自身抗体状态对结果进行分层:水素-4 (AQP4) - IgG阳性,髓寡细胞糖蛋白 (MOG) - IgG阳性,双重血清阴性 (DN).
为了确定抗体状态对视觉恢复的预测值.

主要方法:

从2016年1月到2024年4月重度ON患者 (BCVA ≤1.0 logMAR) 的回顾性队列分析.
使用基于细胞的检测方法对AQP4和MOG抗体进行血清检测.
视觉结果的分类为"良好的恢复" (BCVA改善≥66.77%),以及"完全恢复" (恢复到基线BCVA).

主要成果:

在42名患者中,17名为AQP4-IgG阳性,10名为MOG-IgG阳性,15名为DN.
阳性MOG-IgG患者表现出最佳的视力恢复.
与MOG-IgG阳性患者相比,AQP4-IgG阳性和DN组的良好和完全视力恢复率明显较低.

结论:

抗体状态显著预测了在孤立的ON中长期的视觉结果.
MOG-IgG阳性与最佳视觉恢复有关,而AQP4-IgG阳性与最差的视觉恢复有关.
早期,抗体引导的管理对于优化ON患者的视觉结果至关重要.

关键词:

双重血清阴性双重血清阴性骨髓类寡干细胞糖蛋白抗体与相关疾病相关的抗体.神经脊髓炎光学谱系障碍视神经炎是一种视神经炎.视力敏度视力敏度视力敏度

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