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Updated: May 13, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
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免疫细胞表型与口腔平状菌之间的因果关系:一项大规模的孟德尔随机化研究

Zirui Meng1,2,3,4, Lin Zhao2,3,4, Jianshu Tan2,3,4

  • 1Department of Laboratory Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.

Journal of evidence-based medicine
|December 16, 2025
PubMed
概括

这项研究使用了门德尔的随机化来识别与口腔平坦 (OLP) 相关的免疫细胞表型. 遗传分析显示,特定的调节性T细胞和B细胞具有保护作用,而某些单细胞和CD8亮白细胞增加了OLP风险.

关键词:
门德尔的随机化自身免疫性疾病是一种自身免疫性疾病.有关因果推理的推理.免疫细胞表型的表型在口腔中,有平坦的状.精准医学是一门精准医学.

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...