与慢性胰腺炎相关的生活质量的地理差异:一项国际多中心研究
Misbah Unnisa1, Mahya Faghih2,3, Asbjørn Mohr Drewes4,5
1Pancreas Research Group, Asian Institute of Gastroenterology, Hyderabad, India.
Gastro hep advances
|December 16, 2025
概括
慢性胰腺炎 (CP) 在西方和印度人口之间存在显著差异. 西方患者年龄较大,与酒精有关的CP率较高,报告生活质量和功能较差.
科学领域:
- 胃肠病学 胃肠病学
- 流行病学 流行病学
- 生活质量研究 研究 生命质量研究
背景情况:
- 慢性胰腺炎 (CP) 影响着全球不同的人群,治疗方法一致.
- 现有的研究缺乏对CP患者在不同地理区域的临床特征和生活质量 (QoL) 的直接比较.
研究的目的:
- 调查和比较西方和印度队列之间的慢性胰腺炎患者的人口,临床和QOL差异.
- 确定可能导致 CP 患者体验观察到的差异的潜在因素.
主要方法:
- 这是一项涉及528名确定的CP的成年患者的横截面多中心研究,来自胰腺疼痛联盟.
- 数据收集包括人口统计,临床疾病特征,医院焦虑和抑郁量表 (HADS) 和欧洲癌症研究和治疗组织生命质量问卷核心30 (EORTC QLQ-C30) 评分.
- 研究对象被分为西方 (欧洲/美国) 和印度群体进行比较分析.
主要成果:
- 西方队列 (n=274) 较老 (平均年龄为54.5岁与35.9岁),与印度队列 (n=254) 相比,目前的酒精使用率 (34%与2%) 和酒精病因率 (53%与17%) 更高.
- 西方患者经历了更多的持续疼痛 (50%与20%相比),更高的异位胰腺功能衰竭的患病率 (66%与44%),以及更多的内镜治疗 (61%与43%相比).
- 西方队列报告说,全球健康状况明显下降,身体,角色,认知和社会领域的功能更差.
结论:
- 在西方和印度人口中,慢性胰腺炎患者存在显著的人口,病因和QOL差异.
- 需要进行进一步的研究,以探索导致 CP 患者体验中观察到的这些差异的潜在文化和社会因素.
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