Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Cellular Adaptation II: Hypertrophy01:26

Cellular Adaptation II: Hypertrophy

54
Hypertrophy is the increase in the size of individual cells, resulting in the enlargement of a tissue or organ. Unlike hyperplasia, which involves an increase in cell number, hypertrophy is characterized by an increase in cell volume. This process often occurs in response to higher functional demand or hormonal stimulation, leading to the production of more structural proteins and organelles, thereby enhancing the cells' work capacity.There are two primary types of hypertrophy:...
54

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Heteronemin, a Scalarane Sesterterpenoid, Activates Apoptosis and Non-Apoptotic Ferroptosis and Inhibits Cytoprotective Autophagy in Oral Cancer Cells.

Archivum immunologiae et therapiae experimentalis·2026
Same author

Integrative Analysis of Glycosylation-Related Genes Reveals Prognostic Subtypes, Immune Evasion, and Therapeutic Vulnerabilities in Lung Adenocarcinoma.

Oncology research·2026
Same author

Multi-omics profiling identifies ACP2 as a lysosome-associated biomarker linked to immune dynamics and clinical outcomes in glioma.

Computational biology and chemistry·2026
Same author

Multi-Omics and Single-Cell Dissection Reveals EXT1 as a Glycosylation-Linked Therapeutic Target in Cancer.

Oncology research·2026
Same author

An integrated bulk and single-cell transcriptomic analysis reveals stemness-driven immune regulation and therapeutic vulnerability in colorectal cancer.

Journal of Cancer·2026
Same author

The impact of COVID-19 vaccination on long-term risk of new-onset atrial fibrillation/flutter after COVID-19 infection: A retrospective cohort study.

PloS one·2026

相关实验视频

Updated: May 2, 2026

Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation
12:54

Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation

Published on: March 7, 2018

14.0K

解码短期和长期的细胞适应Cr (VI) 暴露通过高通量转录组学.

I-Jeng Yeh1,2, Chih-Yang Wang3,4,5, Nam Nhut Phan6

  • 1Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.

International journal of medical sciences
|December 16, 2025
PubMed
概括
此摘要是机器生成的。

六价 (Cr(VI)) 暴露会随着时间的推移引发明显的分子变化. 短期暴露会导致急性压力,而长期暴露会促进纤维化,EMT和癌症信号,提供潜在的生物标志物标.

关键词:
这就是Cr (VI) 的意思.生物标志物 生物标志物癌症发生的原因是癌症发生.六价的六价是一种氧化应激是一种氧化应激.翻译学 翻译学 翻译学 翻译学

更多相关视频

Monitoring Protein-RNA Interaction Dynamics In Vivo at High Temporal Resolution Using χCRAC
09:15

Monitoring Protein-RNA Interaction Dynamics In Vivo at High Temporal Resolution Using χCRAC

Published on: May 9, 2020

5.6K
Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes
08:32

Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes

Published on: May 23, 2025

1.1K

相关实验视频

Last Updated: May 2, 2026

Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation
12:54

Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation

Published on: March 7, 2018

14.0K
Monitoring Protein-RNA Interaction Dynamics In Vivo at High Temporal Resolution Using χCRAC
09:15

Monitoring Protein-RNA Interaction Dynamics In Vivo at High Temporal Resolution Using χCRAC

Published on: May 9, 2020

5.6K
Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes
08:32

Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes

Published on: May 23, 2025

1.1K

科学领域:

  • 环境毒理学环境毒理学
  • 分子致癌症的产生.
  • 文字转录学 (Transcriptomics) 是一个学科.

背景情况:

  • 六价 (Cr(VI)) 是一个已知的致癌物质.
  • 对Cr (VI) 暴露的依赖时间的分子效应尚未得到充分理解.

研究的目的:

  • 为了研究对急性或慢性CrVI暴露的转录反应.
  • 确定与Cr (VI) 致癌相关的分子途径和潜在生物标志物.

主要方法:

  • 综合分析了两个转录基因数据集 (GSE16349和GSE24025).
  • 进行MetaCore路径丰富分析.
  • 蛋白与蛋白相互作用 (PPI) 网络分析.

主要成果:

  • 鉴定了250个不同表达的基因,这些基因在短期和长期暴露中都很常见.
  • 短期暴露激活了急性压力反应.
  • 长期暴露诱导了与纤维化,上皮-介质细胞过渡 (EMT) 和瘤信号传递相关的途径.
  • 确定了潜在的关键枢纽基因作为生物标志物.

结论:

  • 随着时间的推移,Cr(VI) 暴露会导致不同的分子轨迹.
  • 这些发现提供了关于Cr (VI) 诱导的致癌的见解.
  • 确定了预防和治疗干预的潜在目标.