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循环纤维细胞生长因子21 (FGF21) 作为肝细胞癌的预后和诊断生物标志物

Joe R Eid¹, Merih Yalciner¹, Lianchun Xiao²

¹Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Journal of hepatocellular carcinoma

|December 16, 2025

概括

在肝细胞癌 (HCC) 患者中,纤维细胞生长因子21 (FGF21) 水平升高与晚期疾病和较差的存活率相关. FGF21可以作为HCC结果的预后生物标志物.

科学领域:

肝病学肝病学是一种肝病学.
内分泌学在内分泌学.
在瘤学瘤学.

背景情况:

纤维细胞生长因子21 (FGF21) 是肝脏分泌的一种激素.
FGF21缺乏与肝病进展有关,包括肝细胞癌 (HCC).
矛盾的是,高FGF21可能与更糟糕的HCC结果有关.

研究的目的:

研究HCC患者血清FGF21水平与临床病理参数之间的关联.
评估血清FGF21水平与HCC的整体存活时间 (OS) 之间的关系.

主要方法:

从767名新诊断的HCC患者 (2001-2014) 收集血液样本.
测量了血清FGF21度,并根据FGF21水平的中位数 (低或高) 分类患者.
作为主要终点分析的整体存活率 (OS).

主要成果:

较高的FGF21水平与先进的HCC特征 (多节瘤,血管入侵,转移,更高的Child-Pugh,CLIP,BCLC,TNM,ECOG得分) 有显著的关联.
与低FGF21患者相比,高FGF21患者的寿命显著缩短 (28%在24个月),低FGF21患者的寿命显著缩短 (43%在24个月).
多变量分析证实高FGF21作为更糟糕的OS的独立预测因素 (HR: 1.422; p < 0.001).

结论:

血清FGF21水平升高与HCC中先进的临床病理特征相关.
高FGF21是HCC患者整体生存率差的重要预测因素.
在HCC中,FGF21可以作为一个有价值的预后和潜在的治疗生物标志物.

关键词:

纤维细胞生长因子 21 21 肝细胞癌是肝细胞癌.总体存活率总体存活率预后生物标志物预后生物标志物

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