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相关概念视频

Batch vs Continuous Culture01:14

Batch vs Continuous Culture

Fermentation is a foundational biotechnological process used to produce pharmaceuticals, biofuels, enzymes, and food additives. Among industrial strategies, batch and continuous fermentation are the two most widely applied. Although both rely on microbial conversion of substrates into desired products, they differ markedly in operation, productivity, and suitability for specific applications.Batch fermentation occurs in a closed system in which nutrient media and inoculum are added at the...
Scale-Up Processes01:14

Scale-Up Processes

The scale-up of microbial fermentation processes is essential in industrial biotechnology, allowing the transition from laboratory-scale experiments to commercial-scale production while aiming to maintain product yield and quality. This process requires meticulous adjustment of equipment design, process parameters, and contamination control strategies to accommodate increasing culture volumes.At the laboratory scale, cultures are typically maintained in 1 to 10-liter glass or autoclavable...
Upstream Processing01:27

Upstream Processing

Upstream processing represents a critical phase in biomanufacturing, wherein biological systems such as microorganisms, mammalian cells, or insect cells are cultivated to produce therapeutic proteins, vaccines, enzymes, or other biologically derived products. This phase encompasses all steps from the selection and genetic manipulation of the production organism to the cultivation of cells in bioreactors under tightly controlled environmental conditions.Host Selection and Genetic OptimizationThe...

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相关实验视频

Updated: May 14, 2026

Directed Cellular Self-Assembly to Fabricate Cell-Derived Tissue Rings for Biomechanical Analysis and Tissue Engineering
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在小规模的连续环层湿颗粒处理过程的过程特征.

Lukas Bahlmann1,2, Jan Henrik Finke1,2, Arno Kwade1,2

  • 1Institute for Particle Technology (iPAT), Technische Universität Braunschweig, Volkmaroder Straße 5, 38104 Braunschweig, Germany.

International journal of pharmaceutics: X
|December 16, 2025
PubMed
概括

环层颗粒化提供了连续的制药生产. 这项研究研究了实验室规模的Granucon颗粒器,发现水分含量显著影响颗粒质量和形态.

关键词:
连续制造 连续制造制造微观结构的微观结构过程参数 过程参数环形层环形层是指环形层.湿颗粒的湿颗粒化方法

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科学领域:

  • 制药工程 制药工程
  • 颗粒技术 颗粒技术
  • 化学工程是化学工程的重要组成部分.

背景情况:

  • 环层颗粒化是一种用于制药生产的连续湿颗粒化方法.
  • 环层工艺的基础研究有限,通常需要大规模的设备.
  • 实验室规模的Granucon颗粒器使小规模的调查成为可能,解决了这一知识差距.

研究的目的:

  • 用实验室规模的Granucon颗粒器研究环层颗粒化过程.
  • 探索关键工艺参数对微晶纤维素颗粒的影响.
  • 了解操作设置对颗粒特性的影响.

主要方法:

  • 使用实验室规模的Granucon环层颗粒器进行连续的湿颗粒.
  • 研究了微晶纤维素的颗粒化,这是一个不溶性材料.
  • 多种工艺参数,包括倾斜速度,粘合剂供应速度和固体供应速度.

主要成果:

  • 湿度被确定为影响颗粒化结果的最关键因素.
  • 轴速和固体料速率影响了颗粒体在颗粒机内的停留时间.
  • 轴速对于环形形成至关重要,并通过机械应力显著影响颗粒形态.

结论:

  • 实验室规模的Granucon颗粒器适用于环层颗粒化的基础研究.
  • 过程参数的优化,特别是湿度控制,对于所需的颗粒性质至关重要.
  • 了解操作参数和机械应力之间的相互作用是控制颗粒形态的关键.