叶酸和甲基马龙酸对心血管疾病死亡率的相互作用作用:流行病学和实验证据
Xinyu Zhang1, Chunping Wang1, Jinfeng Wang1
1Department of Occupational and Environmental Health, School of Public Health, Shandong Second Medical University, Weifang, China.
iScience
|December 16, 2025
概括
高和低的叶酸水平增加心血管疾病 (CVD) 死亡风险,特别是当甲基马龙酸 (MMA) 升高时. 这种相互作用表明,B族维生素状态对于心血管疾病风险评估至关重要.
科学领域:
- 生物化学 生物化学
- 心血管医学 心血管医学
- 营养科学 营养科学
背景情况:
- 叶酸与心血管疾病 (CVD) 的关联是复杂的,并可能受到甲基马龙酸 (MMA) 的影响.
- 了解叶酸,MMA和心血管疾病死亡率之间的相互作用对于公共卫生战略至关重要.
研究的目的:
- 调查MMA在大量人群中对心血管疾病死亡率的独立和相互作用影响.
- 探索叶酸,MMA和心血管结果之间的机制联系.
主要方法:
- 分析了22487名NHANES参与者 (1999-2014) 的数据,平均随访时间为12.1年.
- 统计建模,包括限制立方线,以评估剂量反应关系.
- 在体外研究中使用H9c2心肌细胞和转录组分析来阐明机制.
主要成果:
- 在叶酸和心血管疾病死亡率之间观察到U形关联,而MMA显示出线性关联.
- 较高的MMA (>182nmol/L) 放大了与低水平和高水平的叶酸相关的心血管疾病死亡风险,这表明了显著的添加相互作用.
- 在体外,MMA加剧了心肌细胞中叶酸诱导的细胞毒性,并改变了与炎症相关的基因表达.
结论:
- 叶酸和MMA都独立地影响心血管疾病死亡风险.
- 在高MMA和异常叶酸水平之间存在协同作用,恶化心血管结果.
- 评估功能性B族维生素状况,考虑到MMA水平,对于准确的CVD风险评估和预防策略至关重要.
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