解开纤维肌痛和易怒肠综合征之间的关联:一个系统审查
Roshitha S Bheemaneni1, Priyanka Sakarkar2, Aahana Nigam3
1Medicine, Gandhi Medical College, Secunderabad, IND.
Cureus
|December 16, 2025
概括
纤维肌痛和刺激性肠综合征共享了涉及免疫功能障碍和神经递质失衡的潜在机制. 了解这些重叠可能会导致这些常见疾病的联合治疗.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 纤维肌痛 (FM) 和刺激性肠综合征 (IBS) 经常同时发生,呈现重叠的症状,如疼痛和疲劳.
- 这种并发性疾病往往导致诊断延迟和不理想的管理策略.
研究的目的:
- 在成年人中系统地审查纤维肌痛和刺激性肠综合征的共享病理生理学.
- 焦点领域包括免疫功能障碍,肠道失调,神经递质失衡和肠-大脑轴.
主要方法:
- 2015年至2025年间出版的全文免费英语文章的系统审查.
- 在五个主要数据库 (PubMed,PubMed Central,Google Scholar,Cochrane,ScienceDirect) 进行的搜索.
- 研究选择和质量评估遵循PRISMA 2020指南,结果包括了10项研究.
主要成果:
- 免疫失调,涉及巨细胞和促炎细胞因子,有助于肠道屏障损伤.
- 肠道微生物组和神经递质水平 (例如,血清素,氨酸) 的变化相互影响病原和症状严重程度.
- 内脏过敏与血清激素和酸盐代谢有关,影响疼痛感知.
结论:
- 纤维肌痛和易怒肠综合征之间存在重叠的病理生理机制.
- 向肠道微生物群 (益生菌,便微生物群移植) 显示出治疗潜力,但需要进一步研究.
- 未来的研究应该解决性别差异,血清激素路径和基于微生物组的先进疗法.
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