在绝经后骨质疏松症患者中对阿伦德罗纳特的知识和坚持:来自科伦坡南方三级护理机构的横截面研究
Jenifar Prashanthan1, Amirthanathan Prashanthan2, Niranjala Meegoda Widanege1
1Diabetes and Endocrinology, Colombo South Teaching Hospital, Colombo, LKA.
Cureus
|December 16, 2025
概括
在斯里兰卡的绝经后妇女中,由于复杂的剂量,阿伦德罗纳特的坚持率很低. 药剂师的咨询和理解指示显著提高了对更好的骨质疏松症治疗结果的遵守.
科学领域:
- 药理学和治疗学 药理学和治疗学
- 公共卫生和流行病学
- 老年医学 老年医学
背景情况:
- 在绝经后的妇女中,阿伦德罗纳特治疗的遵守率低于最佳水平,这与复杂的剂量,降低的疗效和骨折风险增加有关.
- 有限的研究存在于使用多变量分析的阿伦德罗纳特坚持的独立决定因素,特别是在南亚人群中.
研究的目的:
- 为了确定斯里兰卡绝经后妇女的阿伦德罗纳特坚持率.
- 确定坚持的独立决定因素,包括对药物与食物相互作用的认识和咨询的影响.
- 评估不同患者教育来源关于合规性的有效性.
主要方法:
- 进行了一项涉及300名绝经后妇女的横截面研究,每周服用70毫克的阿伦德罗纳特至少六个月.
- 通过验证问卷收集的数据评估了剂量遵守,药物-食品-药物组合的知识,副作用和教育来源.
- 多变量逻辑回归分析被用来识别最佳坚持的独立预测因素.
主要成果:
- 只有16.0%的参与者实现了最佳的阿伦德罗纳固化 (得分≥6/7),平均得分为4.0.
- 最佳遵守的独立预测因素包括药师咨询 (aOR=3.24),对说明的全面理解 (aOR=2.89),高等教育 (aOR=2.15) 和郊区居住 (aOR=1.87).
- 关于与普通水以外的液体 (51.3%) 的同时使用,观察到显著的知识差距,62.3%报告了不良反应,主要是胃肠道.
结论:
- 在斯里兰卡的绝经后妇女中,阿伦德罗纳特的遵守率非常低.
- 药剂师咨询和对药物说明的彻底理解是改善药物遵守的关键可修改因素.
- 实施结构化的药物护理计划和针对健康素养的教育材料是提高骨质疏松症管理的必要条件.
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