贾奥泰万激活血清SCFA,并调高抗抑郁作用的cAMP-PKA-CREB-BDNF信号通路:一个多中心,随机,受控研究
Mengnan Huang1,2, Yuanyuan He1, Tong Yang1
1Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Chinese herbal medicines
|December 16, 2025
概括
贾奥塔伊万 (JTW) 通过调节血清短链脂肪酸 (SCFA) 和循环腺单酸 (cAMP) -蛋白激酶A (PKA) -cAMP-反应元素结合蛋白 (CREB) -脑衍生神经营养因子 (BDNF) 途径来缓解抑郁症. 这种传统中医药在改善抑郁症状方面表现有前途.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 代谢学 代谢学 代谢学
背景情况:
- 抑郁症是一种普遍存在的情绪障碍,具有复杂的潜在机制.
- 传统中医 (TCM) 提供了潜在的治疗途径,而贾托伊万 (JTW) 是抑郁症的显著处方.
- 人们对JTW抗抑郁作用的确切科学机制仍然不完全理解.
研究的目的:
- 研究JTW对抑郁症患者血清短链脂肪酸 (SCFA) 水平的影响.
- 阐明循环腺单酸盐 (cAMP) -蛋白激酶A (PKA) -cAMP-反应元结合蛋白 (CREB) -脑衍生神经营养因子 (BDNF) 在JTW抗抑郁作用中的信号通路的作用.
- 揭示JTW在治疗抑郁症的有效性的科学基础.
主要方法:
- 这是一项多中心,随机,受控的研究,涉及120名抑郁症患者.
- 患者被分配到JTW,JTW+选择性血清素再吸收抑制剂 (SSRI) 或SSRI单疗群.
- 使用液态染色体质谱法 (LC-MS) 分析向代谢组分的血清SCFA,同时通过ELISA和RT-PCR评估cAMP-PKA-CREB-BDNF通路.
主要成果:
- 所有治疗组在八周后显示汉密尔顿抑郁症评分表 (HAMD) 和自我评分抑郁症评分表 (SDS) 的得分显著降低.
- 与SSRI组相比,JTW + SSRI组在HAMD分数中表现出更明显的下降.
- 治疗JTW导致cAMP-PKA-CREB-BDNF通路表达的显著增加以及特定的SCFA (异黄油,黄油,异烯酸和烯酸) 的水平升高,特别是在组合治疗组.
结论:
- 贾奥泰万 (JTW) 有效地缓解了患者的抑郁症状.
- JTW的抗抑郁作用与血清SCFA和cAMP-PKA-CREB-BDNF信号通路的调节有关.
- 与JTW和SSRI的联合治疗显示出增强的疗效,这表明涉及SCFA和神经营养信号的协同机制.
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