相关实验视频

Updated: Jan 8, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

在下肢动脉疾病中,DDR1通过NF-Kappa B激活来调节股骨动脉化

Manovriti Thakur^1,2, Thibaut Quillard³, Nico Angliker^1,2

¹Division of Angiology, Swiss Cardiovascular Center, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Acta physiologica (Oxford, England)

|December 16, 2025

概括

这项研究确定DDR1是中枢动脉化 (MAC) 在下肢动脉疾病 (LEAD) 的关键驱动因素. 向DDR1可能提供一种新的治疗方法,以预防LEAD患者的MAC.

科学领域:

血管生物学血管生物学
心血管疾病研究研究
分子医学是分子医学.

背景情况:

下肢动脉疾病 (LEAD) 影响全球2.3亿人,中枢动脉化 (MAC) 在患者中很常见,与死亡率有关.
目前在LEAD中缺少股骨MAC的治疗策略,其潜在的机制需要阐明.
了解股骨MAC的分子驱动因素对于开发向治疗至关重要.

研究的目的:

在患有下肢动脉疾病 (LEAD) 的患者中识别股骨中枢动脉化 (MAC) 的分子驱动因素.

主要方法:

使用von Kossa染色,免疫光和基因表达来分析人类患者样本.
在食西方饮食 (WD) 的Apoe-/-小鼠中评估中间化.
用小鼠和人类血管光滑肌细胞 (VSMC) 进行体外实验,以评估DDR1在化中的作用.

主要成果:

股骨动脉显示显著更高的化和亲化基因表达 (DDR1,BMP2) 与心脏动脉相比.
在人类大腿骨样本中,DDR1表达与化正相关.
DDR1抑制减少了,而激活增加了VSMC中的沉积;DDR1刺激激活了NF-κB,这是一种涉及化的途径.

结论:

DDR1被确定为LEAD中化的关键分子驱动因素,通过NF-κB激活运行.
向DDR1在LEAD中为预防中枢动脉化提供了一个潜在的新型治疗策略.
对DDR1抑制的进一步研究可能会导致对动脉样硬化心血管疾病表现的新疗法.

关键词:

DDR1 DDR1 的使用方法在LEAD特定的化过程中出现化.腿部血管平滑肌肉细胞细胞中部动脉化中部动脉化

更多相关视频

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model

A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model

Published on: November 18, 2022

相关概念视频

Peripheral Artery Disease I: Introduction

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...

NF-κB-dependent Signaling Pathway

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...