基于AI的呼出VOC面板作为肠道微生物群衍生生物标志物用于IBD查
Yongyan Ji1, Zhiheng Yu1, Yuerun Huang1
1Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3), Department of Environmental Science and Engineering, Fudan University, Shanghai 200438, China.
ACS sensors
|December 16, 2025
概括
呼吸分析揭示了炎症性肠病 (IBD) 的明显代谢特征. 这种呼吸学方法提供了一种新的,准确的方法来诊断IBD,并指导微生物向治疗.
科学领域:
- 生物化学 生物化学
- 微生物学 微生物学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 炎症性肠道疾病 (IBD) 由于其复杂性而带来了诊断和治疗方面的挑战.
- 在IBD的异质性需要创新的诊断和治疗策略.
研究的目的:
- 调查呼出的挥发性有机化合物 (VOC) 作为IBD诊断的生物标志物.
- 为了将代谢特征与肠道微生物群组成和IBD活性相关联.
- 开发一种基于呼吸学的IBD诊断和风险分层工具.
主要方法:
- 在244个个体中使用热吸附气色谱-并联质谱分析呼出的VOCs.
- 整合了1660个人的肠道微生物群数据.
- 应用机器学习来识别VOC生物标记面板并开发风险评分系统.
主要成果:
- 在呼出的气息中确定了64种内源代谢物,在IBD患者中具有明显的模式 (碳化合物增加,有机酸/脂质减少).
- 与肠道微生物失调相关的代谢变化,有益细菌减少,氧化应激增加.
- 开发了10个VOC生物标记面板,用于IBD亚型和活动状态,具有高诊断准确性 (AUC = 0.88).
结论:
- 呼吸学为IBD诊断和患者分层提供了一个非侵入性,准确的工具.
- 呼吸中的代谢特征与肠道微生物群失调有关.
- 恢复微生物平衡,例如通过酸盐生产,显示了IBD的治疗潜力.
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