绘制软体动物内分泌的地图:一个系统和批判性的评估
Konstantinos Panagiotidis1, Thomas H Miller1, Olwenn V Martin2
1Environmental Sciences, Department of Life Sciences, Brunel University of London, Kingston Ln, London, Uxbridge UB8 3PH, UK.
Biological reviews of the Cambridge Philosophical Society
|December 16, 2025
概括
软体动物内分泌学研究经常错误地假定脊椎动物的激素通路. 这篇评论强调了不良的方法和需要探索多样化的激素系统超越脊椎动物类固醇的完整理解.
科学领域:
- 进行比较内分泌学.
- 哺乳动物生物学 哺乳动物生物学
- 激素信号通路 激素信号通路
背景情况:
- 传统的软体动物内分泌学研究一直以脊椎动物为中心的观点为主,专注于脊椎动物类型的类固醇激素.
- 关于软体动物合成脊椎动物类型类固醇的能力存在重大争论,原因是有矛盾的证据和缺乏关键酶.
- 这导致了有关软体动物其他潜在激素通路的知识差距.
研究的目的:
- 系统地审查和评估有关类动物中的激素,受体和代谢酶的证据.
- 批判性地评估软体动物内分泌学现有研究的方法严谨性和重点.
- 识别知识缺口,并倡导对软体动物激素信号的更广泛的探索.
主要方法:
- 2012年至2021年间发表的147项符合条件的研究的系统文献搜索.
- 遵守PRISMA-P和COSTER系统审查指南.
- 在交互式在线数据库 (Tableau Public) 中对数据进行总结和可视化.
- 使用偏差风险工具进行批判性评估,并通过比较内分泌学进行叙事综合.
主要成果:
- 发现了显著的方法缺陷,95%的研究未能评估激素受体结合.
- 许多研究采用了不可靠的方法或缺乏可靠的验证,其中83%没有独立重复实验.
- 研究很大程度上偏向于脊椎动物类型的性类固醇 (66%测量了17β-雌激醇),尽管对它们在软体动物中新生合成的证据很弱.
- 缺乏研究的途径,如视网酸信号传递,甲状腺激素,植物和生态类固醇,得到了有限的关注.
结论:
- 在软体动物内分泌学研究中,迫切需要提高实验严谨性和改进方法.
- 该领域应该将重点从以脊椎动物为中心的范式转移到探索多样化和进化保存的激素途径.
- 对研究不足的荷尔蒙系统进行进一步的研究对于全面了解软体动物内分泌学至关重要.
相关概念视频
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00:46What is the Endocrine System?
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01:45Endocrine Signaling
Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
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