肉瘤中的NTRK1-3融合:流行率,意义和临床影响 - 一项系统性审查
Shahd Hamran1, Zaineh Alnoubani1, Aly Mostafa Hassan1
1College of Medicine, QU Health, Qatar University, Doha, Qatar.
Future oncology (London, England)
|December 16, 2025
概括
在肉瘤中,NTRK1-3基因融合是罕见的,但TRK抑制剂具有很高的疗效. 基因组测试对于识别这些融合和指导个性化癌症治疗至关重要.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 分子生物学分子生物学
背景情况:
- 涉及神经营养受体氨酸激酶 (NTRK) 基因的基因融合导致热氨酸受体激酶 (TRK) 的过度表达.
- 通过先进的分子技术检测NTRK1-3融合,可以实现个性化癌症医学,包括TRK抑制剂疗法.
研究的目的:
- 为了调查NTRK1-3基因融合在肉瘤中的患病率和临床意义.
- 评估TRK抑制剂在患有NTRK1-3融合的肉瘤患者中的疗效.
主要方法:
- 在PubMed/MEDLINE,SCOPUS和Web of Science进行了全面的文献搜索.
- 数据综合包括叙事和主题分析,研究质量使用流行病学研究方法论标准 (MASTER) 规模进行评估.
- 基因组测序是主要使用的诊断方法.
主要成果:
- 该分析包括了136项研究,涉及18077名患者. 在551名肉瘤患者中确定了NTRK1-3融合,主要涉及NTRK1和NTRK3.
- 最常见的融合是ETV6-NTRK3.3. 拉罗特雷克提尼布在142名患者中显示出83.80%的应答率,死亡率和复发率较低.
- 恩特雷克提尼布的反应率为63.64%.
结论:
- 证实NTRK1-3融合在肉瘤中是罕见的.
- TRK抑制剂在治疗含有这些融合的肉瘤方面表现出很高的疗效.
- 基因组测试对于所有肉瘤病例至关重要,以确定TRK抑制剂治疗的潜在候选人.
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