耐药 tinea corporis 在低社会经济环境中出现
Harshani Thabrew1, Nayani Madarasinghe2, Surammika Eriyagama3
1Department of Microbiology, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka.
Clinical and experimental dermatology
|December 16, 2025
概括
体的抗治疗性正在增加. 这项研究在斯里兰卡皮肤菌感染中发现了对terbinafine和itraconazole的显著耐药性,这表明在治疗期间需要仔细监测.
科学领域:
- 医学真菌学 医学真菌学
- 抗微生物耐药性 抗微生物耐药性
- 皮肤病学 皮肤病学
背景情况:
- 在 tinea corporis 感染中出现的治疗耐药性构成了临床挑战.
- 复发性皮肤植物病需要对抗真菌敏感性的最新理解.
研究的目的:
- 评估无毛皮肤的皮肤菌感染中的抗真菌耐药性.
- 调查斯里兰卡目前的抵抗模式.
主要方法:
- 在斯里兰卡9个省份进行了一项描述性,观察性,横截面研究.
- 检测了127种皮肤植物分离物 (Trichophyton mentagrophytes和T. rubrum) 的抗真菌敏感性.
- 抗真菌敏感性测试遵循EUCAST E.DEF 9.3 (2015) 的指导方针,并进行质量控制.
主要成果:
- 对特尔比纳和伊特拉可纳观察到高耐药率.
- 25%的T. mentagrophytes分离物显示了超出EUCAST流行病学切线的特比纳MIC.
- 42%的T. mentagrophytes分离物中,伊特拉科纳的MIC超过了流行病学切线.
结论:
- 伊特拉科纳可能是一个可行的治疗选择,但需要密切监测患者.
- 了解局部抗真菌耐药性模式对于有效的 tinea corporis 管理至关重要.
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