肠道微生物群和肺癌的新饮食指数之间的关联:一个基于人口的研究
Tong Wu1, Xiaofei Zhang2, Xiaohan Ma1
1Graduate School, Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
Medicine
|December 16, 2025
概括
肠道微生物群 (DI-GM) 的较高饮食指数与较低的肺癌风险相关. 这项研究表明,DI-GM可能是预防肺癌发展的保护因素.
科学领域:
- 微生物组研究的研究.
- 在瘤学瘤学.
- 营养流行病学 营养流行病学
背景情况:
- 肠道微生物群在各种健康结果中发挥着作用.
- 肠道微生物群多样性与肺癌风险之间的关系尚不清楚.
- 肠道微生物群的饮食指数 (DI-GM) 是微生物群多样性的衡量标准.
研究的目的:
- 调查肠道微生物群的饮食指数 (DI-GM) 与肺癌风险之间的关联.
- 通过使用大型,具有全国代表性的数据集来分析这种关系.
主要方法:
- 利用了国家健康和营养检查调查 (2007-2018) 的数据.
- 包括22473名20岁及以上的成年人.
- 使用加权后勤回归,子组分析和限制立方支线模型,在评估多线性与方差通胀因子后.
主要成果:
- 更高的DI-GM与肺癌的可能性降低显著相关.
- 具有最高DI-GM的参与者患肺癌的风险降低了72% (OR=0.28;95% CI:0.09-0.84).
- 在DI-GM和肺癌风险之间观察到线性负相关性.
结论:
- 这项横截面研究表明DI-GM与肺癌之间存在负面关联.
- 通过DI-GM测量较高的肠道微生物群多样性,可能有助于预防肺癌.
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