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每周用MK-8527进行口服预防,保护 rhesus macaques 免受人免疫缺陷病毒的肠道挑战

Tracy L Diamond1, Yash Kapoor1, Fangbiao Li1

  • 1MRL, Merck & Co., Inc., Rahway, New Jersey, USA.

The Journal of infectious diseases
|December 16, 2025
PubMed
概括

MK-8527,一种新的HIV-1暴露前预防,完全保护子免受猿人免疫缺陷病毒 (SHIV) 感染. 这种核酸逆转录酶抑制剂在进一步的临床开发中显示出它有望预防HIV-1感染.

关键词:
预防HIV-1病毒感染在MK-852727中使用.非人类灵长类的灵长类.暴露前的预防 暴露前的预防猿人免疫缺陷病毒人类免疫缺陷病毒

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