塞法胺和塞法胺/阿维巴克坦在0.45%的化和Plasma-Lyte A中的物理兼容性
Hanna Rowell1, Ronnae M Johnson1, Gabriella Baki1
1University of Toledo College of Pharmacy and Pharmaceutical Sciences, Toledo, Ohio.
International journal of pharmaceutical compounding
|December 16, 2025
概括
这项研究发现,塞夫塔齐迪姆和塞夫塔齐迪姆/阿维巴克坦添加剂显示pH值变化,并且在几个小时内与0.45%化和Plasma-Lyte A物理不相容,影响了静脉注射药物安全性.
科学领域:
- 制药科学 制药科学
- 传染性疾病 传染性疾病
- 临床药房 临床药房
背景情况:
- 静脉注射药物的完整性对于患者的安全和结果至关重要.
- 缺乏静脉注射液体的物理兼容性数据可能会使患者的护理复杂化.
- 这项研究探讨了Ceftazidime和Ceftazidime/avibactam的物理兼容性.
研究的目的:
- 为了确定ceftazidime和ceftazidime/avibactam的物理兼容性.
- 为了评估0.45%的化 (NaCl) 和等离子酸盐A (PLA) 的兼容性.
- 在临床相关度下评估兼容性.
主要方法:
- 在体外分析不同度的塞夫塔齐和塞夫塔齐/阿维巴克坦.
- 在0.45%NaCl和PLA中的添加剂在多个时间点 (0,1,5,8,24小时) 的评估.
- 使用视觉检查,光谱测量和pH分析评估物理兼容性.
主要成果:
- 在添加剂中没有观察到视觉或光谱变化.
- 所有样本都显示出随着时间的推移可证明的pH值变化.
- 塞法胺在0.45%NaCl的初始使用后不相容,在PLA中超过1小时后不相容.
- 塞法胺/阿维巴克坦在1-5小时内在两种静脉注射液中显示不兼容,取决于度.
结论:
- 这项研究提供了新的数据,关于ceftazidime和ceftazidime/avibactam在0.45%NaCl和PLA中的物理兼容性.
- 结果表明身体兼容性有限,突出了临床环境中的潜在风险.
- 建议进行进一步的化学分析,以充分了解添加剂的稳定性.
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