被剥夺自由的人对结核病疫苗研究的看法
Mariana Cristina Campos Falleiros Pires1, Yiran E Liu2, Everton Ferreira Lemos3
1School of Medicine, Federal University of Mato Grosso do Sul, Campo Grande, Brazil.
PLOS global public health
|December 16, 2025
概括
巴西的监禁人员优先考虑明确的信息和参与结核疫苗试验的研究人员问责制. 他们对监狱卫生系统和研究机构的信任大大影响了他们加入临床研究的意愿.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 临床试验 临床试验
背景情况:
- 监狱表现出高结核病 (TB) 率,使监禁人口对疫苗引入至关重要.
- 伦理问题源于在研究中对被剥夺自由的人 (PDL) 的历史剥削.
- 关于参与疫苗研究的PDL观点仍未得到充分探索.
研究的目的:
- 探索PDL对健康,结核病,疫苗和参与结核病疫苗临床试验的看法.
- 了解PDL同意参与研究的条件.
主要方法:
- 一个多中心的定性研究,使用焦点小组讨论.
- 在巴西七个州立监狱中进行,有91名被监禁人员 (2024年2月至8月).
主要成果:
- 参与者报告了获得医疗保健的挑战,并分享了结核病的经验.
- 人们注意到对疫苗和试验的积极看法,这取决于透明度和尊重.
- 对研究机构的信任和先前的医疗保健经验是关键的影响因素.
结论:
- 在结核病疫苗试验中将PDL纳入道德标准需要优先考虑自主性和透明沟通.
- 解决PDL问题和建立信任对于成功参与研究至关重要.
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