发病率和对他类药物治疗的坚持的决定因素:系统审查和元分析
Athanasios Basios1, Georgios Markozannes2,3, Evangelia E Ntzani2,4
1Department of Health Sciences, University of Ioannina, Greece.
European journal of preventive cardiology
|December 16, 2025
概括
对他类药物治疗的良好坚持是次优的,影响超过三分之一的患者. 诸如年龄,性别,种族和并发症等因素会影响他类药物的服用,因此需要针对性干预,以更好地预防心血管疾病.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 类固醇药物治疗对于预防动脉样硬化心血管疾病 (ASCVD) 是至关重要的.
- 了解坚持模式和影响因素对于优化治疗结果至关重要.
- 降脂疗法 (LLT) 的坚持显著影响ASCVD预防策略.
研究的目的:
- 为了确定成年人对他类药物治疗的良好坚持的流行率.
- 在ASCVD预防中确定与他类药物坚持相关的人口和临床因素.
- 为改善危险人群的他类药物治疗遵守率的策略提供信息.
主要方法:
- 在PubMed和Scopus的系统文献搜索到2025年5月.
- 随机对照试验,队列,嵌套病例对照和横截面研究的元分析.
- 纳入了76项与5,898,141名参与者的研究;使用纽卡斯尔-太华尺度和Cochrane RoB 2工具进行质量评估.
主要成果:
- 良好的他类药物坚持 (≥80%的药物使用) 的综合流行率为62.4%.
- 在初级预防 (57.5%) 和二级预防 (64.4%) 中观察到较低的坚持.
- 与较低坚持相关的因素:女性性别,黑人种族,吸烟,抑郁症,心力衰竭. 更高的坚持:老年人,心肌梗塞,高血压,≥2并发症,多药.
结论:
- 达丁类药物治疗的坚持率低于最佳,并受到各种人口和临床因素的影响.
- 有针对性的干预措施对于提高坚持是必不可少的,尤其是在高风险患者群体中.
- 改善他类药物的坚持可以导致更好的ASCVD预防和管理.
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