性别和性别差异在同时出现的物质使用和抑郁症:一个系统的审查
Parker Grant1,2, Maryam Sorkhou1,2, Julia Ryan1,2
1Institute of Mental Health and Policy Research and Addictions Division, Centre for Addiction and Mental Health (CAMH), Toronto, Canada.
The American journal of drug and alcohol abuse
|December 16, 2025
概括
性别和性别显著影响重大抑郁障碍 (MDD) 和物质使用障碍 (SUD) 的同时发生. 了解这些差异对于针对受影响个体量身定制的治疗和自杀预防策略至关重要.
科学领域:
- 精神病学和心理健康 精神病学和心理健康
- 成 药物 药物 药物 药物
- 社会医学科学 社会医学科学
背景情况:
- 重度抑郁症 (MDD) 和物质使用障碍 (SUD) 经常同时发生,性别和性别影响了他们的关系.
- 这些性别和性别差异的具体模式在不同SUD中,在MDD同时发生的个体中并未得到很好的确立.
研究的目的:
- 系统地审查和综合现有关于性别和性别差异的现有证据,包括与四种特定的SUD同时发生的MDD的患病率,临床特征和治疗结果:酒精,大麻,阿片类药物和可卡因使用障碍.
- 确定性别和性别如何影响经历重大抑郁症和物质使用障碍的个体.
主要方法:
- 在PsycINFO,MEDLINE和Embase数据库中进行了系统的文献搜索,遵守PRISMA指南.
- 包括的研究检查了同时发生的MDD和至少一个SUD,结果按性别或性别分类.
- 分析涵盖了47项研究,共有648,414名参与者,来自不同的人口和地区.
主要成果:
- 患有SUD的女性更有可能同时出现MDD,特别是与酒精使用障碍 (AUD) 和阿片类药物使用障碍 (OUD) 一起出现.
- 患有MDD的男性更频繁地与同时发生的AUD相关.
- 同时发生的MDD-SUD增加了自杀风险,特别是在女性中. 治疗结果各不相同,一些证据表明MDD在男性中增加了复发风险,但在女性中降低了复发风险.
结论:
- 性别和性别是MDD和SUD同时发生的个体的风险概况和治疗反应的关键决定因素.
- 研究结果强调了个性化查,有针对性的自杀预防和个性化的复发管理策略的必要性.
- 提高对性别和性别的概念清晰度,以及纳入性别多样化的人口,对于开发公平的临床实践和干预措施至关重要.
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