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在多种农业矩阵中确定4:2甲基硫酸的分析干扰

Christine M Fisher¹, Brian Ng¹, Pierluigi Delmonte¹

¹U.S. Food and Drug Administration, Human Foods Program, 5001 Campus Drive, College Park, Maryland 20740, United States.

Journal of agricultural and food chemistry

|December 16, 2025

概括

研究人员在对农产品的和多醇基物质 (PFAS) 分析中将复杂脂质确定为干扰物. 区分这些干扰物对于在复杂矩阵中准确检测PFAS至关重要.

科学领域:

环境化学环境化学
分析化学分析化学

背景情况:

和多基基物质 (PFAS) 是广泛使用的具有环境持久性的化学物质.
由于潜在的干扰,在农产品等复杂矩阵中精确量化PFAS具有挑战性.

研究的目的:

为了识别在玉米,小提琴头和干草中对4:2甲基硫酸 (4:2 FTS) 的分析中观察到的干扰物.
开发方法来区分4:2 FTS与已识别的干扰物.

主要方法:

液体染色学-双重质谱学 (LC-MS/MS) 使用三重四极.
液体染色学 - 高分辨率质谱学 (LC-HRMS) 和MS/MS.
优化色谱条件和质谱过渡的优化.

主要成果:

科科脂肪酸F和其他复杂的脂质被确定为4:2 FTS的干扰物 (m/z 326.9743).
这些干扰物产生质量电荷比 (m/z) 为327.2177.
成功的分化策略包括HRMS,干扰物的有针对性监测和改变的染色分离.

结论:

复杂的脂质可以干扰农业样本中的 4:2 FTS分析.
实施先进的分析技术和方法调整可以减轻假阳性和PFAS的过度报告.
将已识别的干扰物添加到PFAS干扰清单 (PIL) 中,可以提高复杂样本矩阵的分析准确性.

关键词:

4:2 FTS 的时间.分析干扰剂分析干扰剂角脂肪酸 F 角脂肪酸 F 玉米的快速生长玉米的快速生长小提琴头,花草,花草的花草.通过和多基基物质 (PFAS)

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