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Updated: Jan 8, 2026

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通过体内基因工程来准肝转移中的免疫异质性

Giovanna Giacca1, Mario Leonardo Squadrito1

  • 1Vector Engineering and In vivo Tumor Targeting Unit, San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan 20132, Italy.

Seminars in immunology
|December 16, 2025
PubMed
概括

肝转移 (LMS) 在肝脏的免疫抑制环境中壮成长. 新的免疫疗法利用了对肝脏免疫生物学和先进的基因传递平台的洞察力,以准这一具有挑战性的瘤利基.

关键词:
基因治疗是一种基因疗法.免疫治疗是一种免疫疗法.隐形病毒载体 隐形病毒载体肝脏转移的发生.瘤免疫学 瘤免疫学

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
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