在结直肠癌中,不同的调节性T细胞子集具有对立的功能
Xiao Huang1, Dan Feng2, Sneha Mitra3
1Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Immunity
|December 16, 2025
概括
结直肠癌 (CRC) 中的调节性T (Treg) 细胞具有双重作用. 介素-10-表达 (IL-10+) Treg细胞促进瘤生长,而IL-10-Treg细胞抑制它,提供向的治疗潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 癌症研究 癌症研究
背景情况:
- 调节性T (Treg) 细胞通常与固体器官癌症的不良预后有关.
- 大肠直肠癌 (CRC) 是一个例外,Treg细胞具有复杂的作用.
- 瘤Treg细胞异质性对于了解它们对CRC进展的影响至关重要.
研究的目的:
- 为了研究结直肠癌中瘤Treg细胞的异质性.
- 在CRC的瘤微环境中识别不同的Treg子集.
- 阐明IL-10表达性 (IL-10+) 和IL-10负性 (IL-10−) Treg细胞在CRC中的不同作用.
主要方法:
- 在CRC瘤中分析Treg细胞子集.
- 特定的Treg细胞群体 (IL-10+和IL-10−) 的实验性消耗.
- 瘤生长,IL-17产生和CD4+ T细胞反应的评估.
- 对Treg亚群丰度与患者预后和组织局部化的相关性分析.
主要成果:
- 在CRC中发现了两种不同的瘤Treg子集,具有差异性IL-10表达.
- 选择性耗尽IL-10+Treg细胞通过增加IL-17的产生和瘤细胞的增殖,增强了瘤的生长.
- IL-10-Treg细胞的消耗导致了显著的瘤回归.
- IL-10+和IL-10− Treg的丰度与人类CRC的有利和不利预后相关.
- 在正常结肠组织和瘤中观察到这些Treg子集的相反的丰富模式.
- 在各种人类屏障组织瘤中发现了类似的Treg子集.
结论:
- 在CRC中的瘤Treg细胞表现出基于IL-10表达的功能二分法.
- 在CRC中,IL-10+ Treg细胞起着前瘤作用,而IL-10− Treg细胞具有抗瘤功能.
- 这种功能异质性表明,在CRC和其他屏障组织癌症中,有潜在的选择性向前瘤Treg子集.
- 保持抗瘤Treg功能可能是有效治疗策略的关键.
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