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Updated: Jan 8, 2026

Method for Efficient Refolding and Purification of Chemoreceptor Ligand Binding Domain
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揭示了Cereblon中隐藏的绑定口袋:他的378 形态动力学信息新联体设计

Jiangnan Du1, Cunhong Luo1, Jin Feng1

  • 1Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang 330013, China.

The journal of physical chemistry. B
|December 16, 2025
PubMed
概括

研究人员使用分子动力学模拟来探索Cereblon (CRBN) 结合口袋. 他们发现了一个新的空洞,为设计改进的CRBN向治疗方法提供了机会,具有增强的选择性.

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