局部类固醇戒断:一个严重的,未被认可的皮肤疾病
Fatima N Hamed1, Rhiannon A Bates2, Claire Daley3
1Dermatology, Barnsley Hospital NHS Foundation Trust, Barnsley, UK fatima.hamed@nhs.net.
BMJ case reports
|December 16, 2025
概括
局部类固醇戒断 (TSW) 是长期局部皮质类固醇 (TCS) 使用引起的严重皮肤反应. 本案例报告详细介绍了TSW的复杂性,强调了早期诊断和临床医生的意识,以改善患者管理.
科学领域:
- 皮肤病学 皮肤病学
- 药物不良反应 药物不良反应
背景情况:
- 局部皮质类固醇 (TCS) 广泛用于湿疹和牛皮.
- 长时间使用TCS可以导致局部类固醇戒断 (TSW),这是皮肤对类固醇的依赖.
- 在TCS停止或逐渐缩小后,TSW症状包括烧伤,,红疹和皮肤变薄.
研究的目的:
- 呈现和分析TSW的临床病例.
- 详细介绍一个患者22个月的TSW经历.
- 突出TSW的诊断和管理复杂性.
主要方法:
- 临床病例的介绍.
- 患者22个月的自我报告经验.
- 诊断和管理挑战的剖析.
主要成果:
- 由于呈现的变化,TSW诊断具有挑战性.
- 特斯威的病理生理学是复杂的,并未完全理解.
- 及时识别至关重要,以防止管理不善,并确保患者得到支持.
结论:
- 提高临床医生对TSW的认识至关重要.
- 需要准确的诊断和量身定制的干预措施来管理TSW.
- 对TSW病理生理学和治疗的进一步研究是有必要的.
相关概念视频
Skin Diseases and Disorders
5.1K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.1K
Changes in Skin Color: Clinical Perspectives
3.2K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
3.2K
Skin Cancer
5.7K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.7K
Reticular Dermis
4.4K
The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
4.4K
Hypersensitivities
7.0K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
7.0K
Pulmonary Tuberculosis I
802
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
802


