与代谢功能障碍相关的脂肪性肝病和心力衰竭风险:全国范围的队列研究
Chan Kyeol Kim1, Sangyong Jo2, Kyupin Ha1
1Dong-A University College of Medicine, Busan, Korea (the Republic of).
Heart (British Cardiac Society)
|December 16, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 独立增加心力衰竭的风险. 管理MASLD和心脏代谢风险因素对于预防心力衰竭至关重要.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 与心力衰竭共享路径.
- 之前关于MASLD和心力衰竭风险的研究受到小样本大小和广泛的风险因素分组的限制.
研究的目的:
- 确定MASLD与心力衰竭发病率之间的独立关联.
- 评估特定心脏代谢风险因子 (CMRFs) 对心力衰竭风险的综合影响.
主要方法:
- 从2009-2010年查队伍中分析了218,605名韩国成年人.
- 按脂肪肝指数≥30和至少一个CMRF定义的MASLD;排除其他肝脏疾病,滥用酒精,癌症,肝硬化.
- 在2019年之前确定的心力衰竭事件;用于调整的危险比率 (HRs) 的多变量考克斯比例危险模型.
主要成果:
- 32%的参与者患有MASLD,表现出不太有利的心脏代谢状况.
- 在约9.6年的随访期间,发生了16,340例心力衰竭病例.
- MASLD与心力衰竭风险增加了2.62倍 (aHR2.62);风险增加了更多的CMRF (每CMRF的aHR为1.24).
结论:
- MASLD是发生心力衰竭的独立预测因素,超出了传统的CMRFs.
- 在心力衰竭风险分层策略中应考虑MASLD.
- 早期识别和管理MASLD可能有助于减轻心力衰竭风险.
关键词:
心脏衰竭是因为心脏衰竭.
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