Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

14.0K
Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
14.0K
Cis-regulatory Sequences02:02

Cis-regulatory Sequences

11.5K
Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
11.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

LC-MS profiling of <i>prmt-1</i> and <i>prmt-5</i> knockout <i>C. elegans</i> reveals PRMT-1 substrates and global proteome remodeling.

bioRxiv : the preprint server for biology·2026
Same author

Systematic Identification of Germ Granule Proteins Reveals Specialized Roles in RNAi and Small RNA Inheritance.

bioRxiv : the preprint server for biology·2026
Same author

The ubiquitin-proteasome pathway mediates selective degradation of unloaded Argonaute proteins in C. elegans.

Genetics·2026
Same author

RG motifs promote piRNA-mediated gene silencing in C. elegans.

Nucleic acids research·2025
Same author

Argonaute-siRNA loading via the RNA-binding protein RDE-4 in C. elegans.

bioRxiv : the preprint server for biology·2025
Same author

RG motifs promote piRNA-mediated gene silencing in <i>C. elegans</i>.

bioRxiv : the preprint server for biology·2025

相关实验视频

Updated: Jan 8, 2026

Protein Extract Preparation and Co-immunoprecipitation from Caenorhabditis elegans
07:22

Protein Extract Preparation and Co-immunoprecipitation from Caenorhabditis elegans

Published on: May 23, 2020

9.7K

解码阿尔戈诺特特异性:从C. elegans和超越的洞察力.

Shihui Chen1, Carolyn Marie Phillips2

  • 1University of Southern California.

RNA (New York, N.Y.)
|December 16, 2025
PubMed
概括
此摘要是机器生成的。

小型非编码RNA通过加载到阿尔戈诺特蛋白质来引导基因沉默. 本综述探讨了管理这种精确RNA加载的规则,这对于RNA干扰 (RNAi) 特性至关重要.

关键词:
阿尔戈诺特人是一个阿尔戈诺特人.这里是C. elegans.它们是RNAiRNAi.基因调节 基因调节 基因调节小小的RNARNA小小的RNARNA.

更多相关视频

Automated Analysis of C. elegans Fluorescence Images using SegElegans
06:27

Automated Analysis of C. elegans Fluorescence Images using SegElegans

Published on: October 10, 2025

537
Large-scale Gene Knockdown in C. elegans Using dsRNA Feeding Libraries to Generate Robust Loss-of-function Phenotypes
18:38

Large-scale Gene Knockdown in C. elegans Using dsRNA Feeding Libraries to Generate Robust Loss-of-function Phenotypes

Published on: September 25, 2013

12.4K

相关实验视频

Last Updated: Jan 8, 2026

Protein Extract Preparation and Co-immunoprecipitation from Caenorhabditis elegans
07:22

Protein Extract Preparation and Co-immunoprecipitation from Caenorhabditis elegans

Published on: May 23, 2020

9.7K
Automated Analysis of C. elegans Fluorescence Images using SegElegans
06:27

Automated Analysis of C. elegans Fluorescence Images using SegElegans

Published on: October 10, 2025

537
Large-scale Gene Knockdown in C. elegans Using dsRNA Feeding Libraries to Generate Robust Loss-of-function Phenotypes
18:38

Large-scale Gene Knockdown in C. elegans Using dsRNA Feeding Libraries to Generate Robust Loss-of-function Phenotypes

Published on: September 25, 2013

12.4K

科学领域:

  • 分子生物学分子生物学
  • 遗传学 是一个遗传学.
  • 生物化学 生物化学

背景情况:

  • 小型非编码RNAs通过指导通过阿尔戈纳特蛋白沉默的信使RNAs (mRNAs) 调节基因表达.
  • RNA干扰 (RNAi) 是一种对生物过程至关重要的保存机制,它依赖于特定的小RNA-Argonaute相互作用来识别目标.

研究的目的:

  • 综合当前关于小RNA加载到阿尔戈诺特蛋白质的特异性的知识.
  • 为了研究影响选择性阿尔戈诺特加载的因素,使用Caenorhabditis elegans作为模型系统.

主要方法:

  • 关于小RNA生物发生和阿尔戈纳特蛋白相互作用的现有文献的审查.
  • 将Caenorhabditis elegans的发现与其他生物体的数据相结合.
  • 对生物化学性质,结构特征,翻译后修饰和表达模式的分析.

主要成果:

  • 小RNA加载特异性是由多种因素的复杂相互作用主导的.
  • 生物发生,RNA特性,阿尔戈诺特结构,修饰和表达模式共同确保精确的加载.
  • 型虫提供了一个有价值的模型来研究这些复杂的加载机制.

结论:

  • 了解Argonaute加载特异性是破译RNAi通路忠实性的关键.
  • 多层调节确保正确的小RNA与它们的同类阿尔戈诺亚特伙伴结合.
  • 进一步的研究,特别是在像C. elegans这样的模型生物体中,将揭示控制这种基本生物过程的准确规则.