ангиотензин-(1-7) 缓解了多微生物败血症小鼠的肠道屏障功能障碍和失生症
Jun Wang1,2, Jierui Li3,4, Yuhan Li5
1Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
British journal of pharmacology
|December 16, 2025
概括
ангиотензин-(1-7) [Ang-(1-7) ] 保护免受败血症诱导的肠道屏障功能障碍和肝损伤. 这种疗法通过调节肠道微生物组和NLRP6炎症组来恢复肠道平衡,为败血症提供了有前途的治疗方法.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 肠道在败血症开始时至关重要.
- 肠道屏障的完整性对于防止细菌转移至关重要.
- ангиотензин-(1-7) [Ang-(1-7) ]在败血症治疗中显示出潜力,但其对肠道屏障功能障碍的影响尚不清楚.
研究的目的:
- 在小鼠模型中研究Ang-(1-7) 对败血症引起的肠壁功能障碍和肠道失调的治疗作用.
主要方法:
- 在C57BL/6小鼠中通过结和穿孔 (CLP) 诱导的败血症模型.
- 评估死亡率,肠道和肝脏组织组织学和生物化学.
- 便微生物群移植 (FMT) 评估肠道微生物群的作用.
- 对于微生物组和代谢概况的16S rDNA和代谢学.
主要成果:
- 血Ang-(1-7) 水平在败血症患者中降低.
- 在CLP小鼠中,外源性Ang-(1-7) 减轻了肠道屏障功能障碍和肝损伤.
- -1-7对肠道的保护作用取决于肠道微生物群.
- Ang-(1-7) 治疗增加了 Lactobacillus gasseri 丰富度,从而激活了 NLRP6 炎症酶,以调节抗菌.
结论:
- Ang-(1-7) 通过调节肠道平衡和NLRP6炎症体,保护免受败血症引起的肠壁功能障碍和肝损伤.
- Ang-(1-7) 是在败血症中肠道平衡的潜在治疗剂,对临床治疗有影响.
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