艾滋病毒对多发性硬化症残疾进展的影响:一项观察性回顾性匹配队列研究
A Moulignier1, J Guillaume2, V Pourcher3
1Department of Neurology, Tertiary Multiple Sclerosis Center, Adolphe de Rothschild Hospital Foundation, Paris, France; Infectious and Tropical Diseases Department, Tenon Hospital, Sorbonne University, Assistance Publique-Hôpitaux de Paris, Paris, France.
Revue neurologique
|December 16, 2025
概括
与没有艾滋病毒的人相比,艾滋病毒和多发性硬化症 (MS) 患者表现出类似的长期残疾进展,尽管接受治疗的次数较少. 这表明艾滋病毒可能不会加剧MS的结果,但需要更多的研究.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 艾滋病毒感染和多发性硬化症 (MS) 之间的相互作用尚不清楚.
- 有限的现实世界数据存在于HIV如何影响MS进展.
研究的目的:
- 将艾滋病毒和多发性硬化 (MS-PLWHIVs) 患者的长期残疾结果与匹配的HIV阴性多发性硬化对照 (MS-controls) 进行比较.
主要方法:
- 使用来自两个法国多发性硬化中心 (1991-2021) 的数据进行了观察性回顾性队列研究.
- 根据MS亚型,性别,第一次MS发作时的年龄以及第一次和第二次发作之间的间隔,MS-PLWHIV与MS控制组进行了匹配.
- 测量的主要结果是达到持续EDSS-6的时间 (需要长达12个月).
主要成果:
- 与对照组相比,MS-PLWHIV患者接受的MS疾病修饰疗法 (MS-DMT) 显著减少.
- 尽管治疗减少了,但MS-PLWHIV患者的EDSS-6达到的时间比对照组晚了8年 (22.8年 vs 14.5年,P=0.05).
- 达到EDSS-6的调整后风险在各组之间没有显著差异 (aHR:1.60).
结论:
- 与艾滋病毒阴性MS患者相比,艾滋病毒和MS患者的残疾进展并没有变得更糟,尽管接受了较少的治疗.
- 与艾滋病毒相关的免疫调节可能在MS进展中发挥作用,但这需要进一步调查.
- 这些发现提供了关于艾滋病毒和多发性硬化综合症的有价值的长期数据,尽管研究的局限性包括样本规模小和回顾性设计.
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