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Updated: Jan 8, 2026

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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关于在cysteinyl leukotriene受体2的ago-allosteric调制的分子见解

Mu Li1, Xiaoling Bao2, Wanbiao Chen3

  • 1The Affiliated Traditional Chinese Medicine Hospital, GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Disease, State Key Laboratory of Respiratory Disease, Guangzhou, Guangdong, China.

Nature communications
|December 16, 2025
PubMed
概括

研究人员发现了由cysteinyl leukotrienes (CysLTs) 激活cysteinyl leukotriene受体2 (CysLT2R) 的结构基础. 这一发现揭示了CysLTs如何调节受体活性,为新药开发铺平了道路.

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