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Updated: Jan 8, 2026

A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins
16:10

A TIRF Microscopy Technique for Real-time, Simultaneous Imaging of the TCR and its Associated Signaling Proteins

Published on: March 22, 2012

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嵌入膜的人类T细胞受体-CD3复合体的静止状态和连接体结合状态

Ryan Q Notti1,2, Fei Yi3,4,5, Søren Heissel6

  • 1Laboratory of Molecular Electron Microscopy, The Rockefeller University, New York, NY, USA. rnotti@rockefeller.edu.

Nature communications
|December 16, 2025
PubMed
概括

T细胞受体 (TCR) 静止状态是一种封闭的构造,与它在结合人类白细胞抗原 (HLA) 时的开放状态不同. 这种形状变化对T淋巴细胞激活至关重要,并提供了新的治疗策略.

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