利多卡因的局部输送使用局部麻醉的螺纹
Chi Zhang1,2,3, Ping Yang1,2,4, Xueke Lin1,2
1Department of Marine Biological Science & Technology, College of Ocean & Earth Sciences, Xiamen University, Xiamen, 361102, China.
这项研究引入了一种新的海绵衍生微针系统,以增强局部麻醉. 与传统方法相比,这种无针的方法显著加快和加强了疼痛缓解.
科学领域:
- 生物材料科学 生物材料科学
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 局部麻醉因局部麻醉剂的皮肤透性差而受到局部麻醉的限制.
- 传统方法的结果是开始缓慢,有效性降低.
- 需要新的传递系统来克服角层屏障.
研究的目的:
- 开发和评估一种新的尖头辅助局部输送系统,以增强局部麻醉剂的吸收.
- 为了研究海绵海里克洛纳 sp. 的疗效. (SHS) 结合卡博默凝用于利多卡因化 (LH) 输送.
- 评估麻醉效应的通过皮肤吸收,发作和持续时间.
主要方法:
- 使用的海绵哈利克洛纳 sp. 在碳化合物凝配方中分散的微针形式的螺纹 (SHS).
- 在体外评估了通过皮肤通过皮肤通过皮肤吸收利多卡因化物 (LH).
- 评估了体内麻醉效果,并进行了试点临床试验.
主要成果:
- 在体外,SHS显著增加了LH皮肤吸收的近十倍.
- SHS促进了LH快速透到更深层的皮肤层.
- 在体内研究表明,在10分钟内产生最大的麻醉作用,明显比常规局部应用快得多.
- 试点临床试验证实了减半发病时间和延长麻醉效果.
结论:
- 基于SHS的分散微针系统为局部麻醉提供了一个快速,安全和无针的替代方案.
- 与传统的局部配方相比,这种系统大大改善了通过皮肤递送药物的效果.
- SHS代表了增强局部麻醉疗效和患者体验的有希望的方法.
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