[免疫检查点抑制剂的副作用:专注于肺部事件]
1Institut für Radiologie, Neuroradiologie und Nuklearmedizin, Ruhr-Universität Bochum, Johannes-Wesling Klinikum, Minden, Hans-Nolte-Str. 1, 32429, Minden, Deutschland. Alexey.Surov@muehlenkreiskliniken.de.
Radiologie (Heidelberg, Germany)
|December 16, 2025
概括
免疫检查点抑制剂 (ICI) 通过增强抗瘤免疫力,彻底改变了癌症治疗. 虽然通常比化疗毒性低,但ICI治疗可能会导致免疫媒介不良事件 (iAEs),特别是影响肺部.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
背景情况:
- 免疫检查点抑制剂 (ICI) 代表了癌症治疗的重大进展.
- ICI通过消毒T细胞介导的抗瘤免疫反应来起作用.
- 与传统化疗相比,ICI提供了更有利的毒性概况.
研究的目的:
- 审查和总结与ICI治疗相关的肺免疫介导不良事件 (iAEs) 的发生和特征.
主要方法:
- 文献综述侧重于报告ICI治疗患者肺部IAE的研究.
- 对这些事件的发生率,临床表现,诊断方法和管理策略的临床数据的分析.
主要成果:
- 肺部IAE是ICI治疗的公认并发症.
- 这些事件可以表现为各种临床和放射性特征,经常模仿其他肺病理.
- 早期识别和适当的管理对于有利的结果至关重要.
结论:
- 在接受ICI的患者中,肺部IAEs是重要的考虑因素.
- 对于呼吸道症状的警和及时的诊断工作是必不可少的.
- 管理策略旨在减轻肺损伤,并在可能的情况下允许继续癌症治疗.
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