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Updated: Jan 8, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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[在转移性割抵抗性前列腺癌中使用多 (ADP-ribose) 聚合酶抑制剂组合治疗]

Carsten Ohlmann1, Christian Gratzke2, Laura-Maria Krabbe3

  • 1Klinik für Urologie, Johanniter-Kliniken Bonn, Johanniterstr. 3-5, 53113, Bonn, Deutschland. Carsten.Ohlmann@bn.johanniter-kliniken.de.

Urologie (Heidelberg, Germany)
|December 16, 2025
PubMed
概括

聚氨酸二酸聚合酶抑制剂 (PARPi) 与新激素药物 (NHA) 结合,在转移性割抵抗性前列腺癌 (mCRPC) 中显示出更好的疗效. 对HRR突变的遗传测试对于有效的治疗计划至关重要.

关键词:
组合疗法是一种联合疗法.单疗法是一种单疗法.突变 突变 突变 突变在 PARP 抑制剂.重组修复的重组修复.

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