美国的精益 MASLD 在美国. 成年人:未被诊断的负担和代谢特征来自NHANES 2017-2020年
Basile Njei1,2,3,4,5, Sarpong Boateng6, Mouhand Mohamed7
1Section of Digestive Diseases, Yale University, New Haven, CT, USA. basile.njei@yale.edu.
Journal of general internal medicine
|December 16, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 影响6.4%的瘦身美国成年人,超过三分之一未被诊断. 对于这个经常被忽视的人群,需要早期检测策略.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
- 公共卫生 公共卫生
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD),以前称为NAFLD,影响全球许多人.
- MASLD发生在瘦个体中,这是当前查经常错过的一个群体.
- 了解精益MASLD对于临床管理至关重要.
研究的目的:
- 确定美国瘦身成年人中MASLD的全国流行率.
- 评估该人口中未被诊断的MASLD的程度.
- 在瘦肉个体中识别与MASLD相关的特征.
主要方法:
- 分析了NHANES 2017-2020年年龄在18岁以上的成年人的数据.
- 通过振动控制的瞬态弹性图 (CAP ≥274 dB/m) 进行MASLD诊断.
- 瘦身状态定义为BMI<25 kg/m2 (或亚洲人<23 kg/m2);排除病毒性肝炎/重度酒精使用.
主要成果:
- 在瘦身成年人中,MASLD的全国估计患病率为6.4% (3.8百万个人).
- 34.6% (1.1800万) 的瘦肉性MASLD病例没有被诊断出来.
- 瘦身MASLD患者的血压,甘油三,禁食葡萄糖和BMI在瘦身范围内较高.
结论:
- 在美国,瘦身肌肉疾病 (Lean MASLD) 很普遍,而且经常没有被诊断出来.
- 目前的查需要针对瘦肉人群进行改进.
- 需要有针对性的策略和风险分层来早期检测具有代谢风险因素的瘦个体.
相关概念视频
01:24Overview of Lipid Metabolism
4.7K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
4.7K
01:20Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
159
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
159
01:24Obesity
1.1K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.1K
01:28Overview of Fatty Acid Metabolism
36.2K
Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
36.2K
01:24Metabolic States of the Body: Fasting and Starvation
2.6K
During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
2.6K
01:18Metabolic States of the Body: The Postabsorptive State
1.2K
The postabsorptive state usually starts about four hours after a meal and lasts until the next meal is eaten. During this time, the digestive system stops absorbing nutrients, and the body uses stored energy reserves to maintain stable blood glucose levels.
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
1.2K