一个患有水的孩子的巨细胞激活综合征:一个病例报告
H Mateiko1, O Synoverska2, M Matvisiv1
1Department of Children Infectious Diseases, Ivano-Frankivsk National Medical University, Sahaidachnogo Street 66, Ivano-Frankivsk, Ukraine.
Journal of medical case reports
|December 16, 2025
概括
巨细胞激活综合征是一种严重的疾病,诊断可能很复杂,特别是在患有白的儿童中. 早期识别和治疗对于管理这种高炎症反应至关重要.
科学领域:
- 儿科风湿病学 儿科风湿病学
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 大细胞激活综合征 (MAS) 是一种危及生命的血细胞性淋巴细胞结核症并发症.
- 它涉及免疫系统过度激活,通常由自身免疫性疾病或诸如疹病毒等感染引发.
- 关键的症状包括发烧,淋巴结和脏膨胀,肝衰竭,出血,低血计数和高费里.
研究的目的:
- 要突出巨细胞激活综合征 (MAS) 的诊断挑战.
- 在流感康复期间,在儿童中呈现MAS病例.
- 强调及时诊断和干预MAS的重要性.
主要方法:
- 一个10岁的乌克兰女孩患有MAS的详细临床病例介绍.
- 描述初始症状,包括皮疹,器官功能障碍 (寡尿症) 和实验室检测结果 (血小板缺血,贫血,低纤维蛋白质,高蛋白质).
- 治疗反应的记录,包括抗生素,葡萄糖皮质类固醇,IVIG和血液透析.
主要成果:
- 患者患有广泛的出血性皮疹与表面亡,最初被误诊为脑膜炎球菌感染.
- 尽管初始治疗,寡尿症持续,需要血液透析,以恢复功能.
- 实验室标志物证实了MAS,包括细胞分解综合征,急性功能衰竭,胰岛素减肥和显著升高的费里水平.
结论:
- 这一案例强调了MAS的诊断复杂性,特别是其多种不同的皮肤表现.
- 迅速识别MAS至关重要,即使症状模仿其他严重感染.
- 多系统参与 (肝脏,脏) 和特定的实验室发现是准确的MAS诊断和管理的关键.
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