透气血压与中风后认知障碍之间的关联:现实世界的回顾性队列研究
Defei Chen1, Tailin Ran1, Yuhui Li1
1Department of Rehabilitation Medicine, Key Laboratory of Physical Medicine and Precision Rehabilitation of Chongqing Municipal Health Commission, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Annals of medicine
|December 16, 2025
概括
在中风后康复期间的低透静血压 (DBP) 是中风后认知障碍 (PSCI) 的重要危险因素. 保持DBP高于80mmHg可能有助于预防中风幸存者的PSCI.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 康复医学 康复医学 康复医学
背景情况:
- 脑卒中后认知障碍 (PSCI) 是中风后的常见并发症.
- 有效的血压管理对于中风幸存者恢复至关重要.
- 腹筋血压 (DBP) 在康复期间对PSCI风险的具体影响尚不清楚.
研究的目的:
- 调查中风后康复期间DBP水平与发展PSCI的风险之间的关联.
- 在现实临床环境中确定DBP作为PSCI潜在的可修改风险因素.
主要方法:
- 分析了2022年5月至2024年3月期间入院的508名中风患者.
- 应用单变量和多变量物流回归来确定PSCI风险因素.
- 利用受限立方斜线 (RCS) 分析来建模DBP和PSCI之间的非线性关系.
- 进行了子组分析,以评估不同患者人口统计学中的DBP影响.
主要成果:
- 在较低的DBP和增加的PSCI风险之间发现了显著的关联 (OR=0.960每mmHg,p<0.01).
- RCS分析发现了一个非线性DBP-PSCI关系,其拐点约为80 mmHg.
- 与75-80mmHg (OR=2.606,p<0.01) 的患者相比,DBP<75mmHg的患者患PSCI的风险要高得多.
结论:
- 在中风后康复期间的DBP与PSCI发病率非线性相关.
- 低DBP是开发PSCI的一个独立风险因素.
- 在康复期间保持DBP高于80mmHg可能是预防PSCI的关键策略.
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