在养老院使用批量质量保证采样进行局部抗生素耐药性监测:可行性研究
Sacha Kuil1,2,3, Roisin Bavalia1, Anders Boyd1,3,4,5
1Department of Infectious Diseases, Public Health Service of Amsterdam, Amsterdam, the Netherlands.
The Journal of antimicrobial chemotherapy
|December 17, 2025
概括
批量质量保证采样 (LQAS) 是追踪养老院抗生素耐药性 (ABR) 的可行方法. 然而,建立关于ABR值的共识对于指导抗生素治疗决策至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生监督 公共卫生监督
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 在养老院相关的尿路感染 (UTI) 中,抗生素耐药性 (ABR) 构成了重大挑战.
- 需要有效的监测方法来监测和控制这些脆弱人群中的ABR.
研究的目的:
- 评估使用批量质量保证采样 (LQAS) 来识别荷兰养老院抗生素耐药性尿病原体高患病率的可行性.
- 探索与ABR相关的因素,并确定基于LQAS的监控的实施要求.
主要方法:
- 在荷兰的三个养老院组织中进行了一项横截面研究.
- 批量质量保证采样 (LQAS) 适用于大肠杆菌/克莱布塞拉菌种类. 从患有尿路感染的居民中分离出来.
- 设定了阻力值,元回归分析确定了ABR决定因素;重点小组探索了实施.
主要成果:
- 在所有组织中,Amoxicillin-clavulanic acid对抗生素耐药性的LQAS分类是"高".
- 较高的ABR患病率与康复病床比例,共享浴室,住院和抗生素使用等因素有关.
- 焦点小组强调了设定ABR门和经验性抗生素治疗 (EAT) 复杂决策过程中的挑战.
结论:
- 批量质量保证采样 (LQAS) 是一种可行的监测方法,用于在4个月的时间内在养老院检测抗生素耐药性.
- 关于可接受的ABR值的共识是必要的,以有效指导局部经验性抗生素治疗 (EAT) 决策.
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