关于实体器官移植接收者和捐赠者的抗生素预防方法的国际调查,这些接受者和捐赠者被多药耐药生物殖民
Julia Bini Viotti1,2, Stephanie M Pouch3, Maddalena Giannella4,5
1University of Miami, Miami, Florida, USA.
概括
在全球范围内,查多药耐药生物体 (MDROs) 和在固体器官移植 (SOT) 中使用抗生素预防的做法有很大差异. 标准化的指导方针对于预防捐赠者和接受者的感染至关重要.
科学领域:
- 移植医学 移植医学
- 传染性疾病 传染性疾病
- 抗微生物药物管理委员会
背景情况:
- 多种耐药生物体 (MDRO) 的殖民和感染在固体器官移植 (SOT) 中带来了重大风险,影响了外科手术期间的抗生素管理.
- 目前在被殖民的捐赠者和接受者中进行查和抗生素预防的国际实践定义不佳.
研究的目的:
- 在SOT内评估MDRO查和术后抗生素管理的全球实践.
- 为了确定管理殖民捐赠者和接受者的协议的国际变化.
主要方法:
- 从2月到2025年7月,在全球移植中心进行了一项基于网络的调查.
- 这项由移植传染病专家开发的调查收集了关于查协议,预防和殖民管理的数据.
- 相关专业协会的认可确保了专家的投入和广泛的覆盖范围.
主要成果:
- 来自24个国家的125个中心的回复显示,MDRO查和预防的国际差异很大.
- 超过一半的中心基于捐赠者MDRO殖民的修改预防,主要来自尿液和呼吸道培养.
- 接受者查的目标是耐卡巴胺的肠道细菌,超过40%的接受者对最近殖民的接受者进行了预防调整.
结论:
- 在SOT的MDRO查和外科期间预防实践中存在显著的国际差异.
- 迫切需要基于证据的共识指导方针来规范实践并改善全球的感染预防.
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