基于丝纤维素的纳米载体用于抗癌药物输送:进展,机制和未来的前景

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Qinjing He¹, Dongmei Li¹, Yuanyuan Xu¹

¹Department of Oncology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.

Nanomedicine (London, England)

|December 17, 2025

概括

丝纤维素 (SF) 提供了一个自然的,生物相容的平台,用于先进的抗癌药物输送. SF纳米粒子增强瘤向性和降低毒性,改善精密瘤学的患者结果.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
在瘤学瘤学.

背景情况:

传统化疗面临着诸如全身毒性和瘤特异性差等局限性.
丝纤维素 (SF),一种天然聚合物,由于其生物相容性和生物降解性,为药物输送提供了一个有希望的替代品.

研究的目的:

审查丝纤维蛋白作为先进抗癌药物输送系统的多功能平台的潜力.
探索SF的特性,制造方法,准策略和开发有效癌症治疗的挑战.

主要方法:

关于丝纤维素纳米粒子制造 (溶解,盐分) 和替代输送形式 (水凝,微球,纤维) 的文献综述.
分析被动 (EPR效应) 和主动准机制 (联结结合).
评估SF对瘤微环境刺激的响应性,用于特定部位的药物释放.

主要成果:

由于SF的结构性质,可以有效地封装药物并控制释放.
物理化学参数,如粒子大小和表面电荷,影响治疗疗效.
基于SF的载体显示出增强瘤向和降低系统毒性的潜力.

结论:

丝纤维素是开发下一代抗癌药物输送系统的非常有前途的生物材料.
基于SF的系统一致性和可扩展性的挑战需要解决临床翻译.
未来的研究方向包括多功能SF混合物和组合药物加载,以改善癌症治疗.

关键词:

丝纤维素是一种丝纤维素.有控制释放的释放.药物输送是药物输送的过程.纳米载体的纳米载体瘤微环境是一个微环境.

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