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使用超临界抗溶剂技术制造贝卡林固体分散剂:优化,表征和评估
Mingming Wang1, Zan Sun2, Jian Hu1
1School of Pharmaceutical Engineering, Jiangsu Food & Pharmaceutical Science College, Huai, P.R. China.
Pharmaceutical development and technology
|December 17, 2025
概括
研究人员改善了baicalinalinalin的性能.
科学领域:
- 药理学 药理学是指药理学的学科.
- 材料科学 材料科学 材料科学
- 化学工程是化学工程的重要组成部分.
背景情况:
- 贝卡林是来自Scutellaria baicalensis的强效黄类糖化物,由于溶解性和生物利用性差,它面临临临床限制.
- 增强baicalin的物理化学特性对于其治疗应用至关重要.
研究的目的:
- 使用超临界抗溶剂 (SAS) 工艺制备贝卡林的无形固体分散物.
- 优化SAS过程,以提高贝卡林溶解和生物可用性.
- 为了评估准备的卡林固体分散的抗菌性质.
主要方法:
- 超临界抗溶剂 (SAS) 工艺采用基于盒式设计 (BBD) 的优化参数 (温度,压力,二氧化碳流速).
- 使用扫描电子显微镜 (SEM),富里埃变换红外光谱 (FTIR),差分扫描热度计 (DSC) 和X射线衍射 (XRD) 进行无形固体分散的表征.
- 在实验室溶解试验和在小鼠体内药理动力学研究.
主要成果:
- 在SAS过程中成功地产生了无形贝卡林固体分散物 (BASD).
- 与原始贝卡林相比,BASD在pH值6.8的可溶性增加了9.4倍,生物可用性增加了1.8倍.
- 根据BASD的研究结果,它对细菌细菌和大肠杆菌有显著的抑制作用.
结论:
- 优化BBD的SAS工艺是有效的准备无形贝卡林固体分散,提高溶解度和生物可用性.
- 增强的贝卡林配方显示出改善治疗疗效和抗菌应用的潜力.
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