聚焦微塑料:对肝脏健康的沉默破坏者 - - 一项系统性审查
Zahra Beyzaei1, Bita Geramizadeh2, Zahra Bagheri3
1Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Frontiers in pharmacology
|December 17, 2025
概括
在细胞和有机体模型中,聚乙烯微型和纳米塑料 (PS-MNPs) 会导致肝损伤,包括氧化应激和代谢功能障碍. 人类研究表明潜在的胎盘转移和与肝脏疾病的联系,突出显示了塑料污染的风险.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 微塑料和纳米塑料 (MNP) 是普遍存在的环境污染物.
- 它们对人类肝脏健康的具体影响仍然不完全理解.
- 聚乙烯颗粒 (PS-MNPs) 是常见的环境污染物.
研究的目的:
- 系统地审查和综合关于聚烯微型和纳米塑料 (PS-MNPs) 肝毒性影响的证据.
- 评估PS-MNP对体外,器官和人体模型中的肝脏健康的影响.
- 确定知识差距,并建议未来的研究方向,PS-MNP肝毒性.
主要方法:
- 按照PRISMA指南进行的25项研究 (2022-2025) 的系统审查.
- 从主要的科学数据库 (PubMed,EMBASE,Scopus,Web of Science) 选了770个记录. 这些数据库包括:
- 使用纽卡斯尔-太华尺度进行质量评估,包括研究.
主要成果:
- 实验室研究始终表明PS-MNP会诱导肝细胞中的氧化应激,炎症,亡和代谢障碍.
- 机体模型显示PS-MNP会破坏硫氨基酸和铁平衡,损害线粒体功能,并导致脂质积累.
- 有限的人类数据表明,胎盘转移和与胎儿肝酶升高和肝硬化病症相关联.
结论:
- 聚烯微型和纳米塑料破坏肝脏的氧化还原平衡,代谢功能和结构完整性.
- 来自各种模型的证据表明,肝毒性潜力显著,纳米塑料更有毒.
- 标准化研究方法和纵向人体研究对于准确的风险评估和缓解策略至关重要.
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