心血管疾病的老年人认知能力和阶段角度之间的关系:一个横截面研究
Huan Peng1, Jie Huang2, Yinwei Qiu3
1The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People's Republic of China.
Clinical interventions in aging
|December 17, 2025
概括
低相角 (PhA) 与患有心血管疾病 (CVD) 的老年人认知障碍有关. 这种非侵入性测量可能有助于在心血管疾病患者中早期检测认知衰退.
科学领域:
- 老年学是一门学科.
- 心脏病学 心脏病学
- 神经学 神经学
背景情况:
- 患有心血管疾病 (CVD) 的老年人认知能力下降是一个越来越令人担忧的问题.
- 慢性炎症,氧化应激和细胞功能障碍是关键调解因素,但早期检测生物标志物缺乏.
- 阶段角 (PhA),生物电阻分析 (BIA) 参数,反映了细胞健康状况,可能表明认知障碍.
研究的目的:
- 为了研究PhA与心血管疾病的老年人认知能力之间的关联.
- 探索PhA作为一种潜在的生物标志物,用于在这个人群中早期检测认知障碍.
主要方法:
- 一项对340名心血管疾病患者 (平均年龄为80.8岁) 的横截面研究,来自江老年人健康监测队列.
- 使用InBody S10测量了PhA;使用迷你精神状态检查 (MMSE) 评估认知功能.
- 用二进制后勤回归和ROC曲线分析来评估PhA和认知能力之间的关联.
主要成果:
- 认知障碍组 (n=138) 与认知正常组 (n=202) 相比,具有显著较低的PhA (P < 0.001).
- 降低的PhA在调整多个共变量后独立地与认知障碍风险相关 (OR = 0.62,P = 0.01).
- 确定了4.75°的最佳PhA值,以70.3%的特异性检测认知障碍.
结论:
- 降低PhA与老年心血管疾病患者的认知障碍独立相关.
- PhA测量是非侵入性的,具有成本效益,并显示出作为社区查工具的潜力.
- PhA可以作为早期干预策略的关键目标,以减轻这一群体的认知衰退.
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